%%EOF It breaks down quickly when exposed to sunlight. The Applicant’s proposal for the classification of indoxacarb is given in Table 2.1. endstream endobj 79 0 obj <>stream It is considered as a “reduced-risk” pesticide which replaces organophosphate pesticides. Indoxacarb (DPX-MP062) has low acute oral toxicity (LD50= 1730 mg/kg bw) in male rats and moderate oral toxicity (LD50= 268 mg/kg bw) in female rats, and low dermal (LD50> 5000 mg/kg bw) and inhalation toxicity (DPX-JW062; LC50= 4200 mg/m3 (4.2 mg/L) in rats. This case demonstrates that findings from animal studies, such as seizures, respiratory distress, and intravascular hemolysis are possible following self-poisoning in humans. 1. D� �/5R;����'�K�(/��UyFz��d�(�z*��A%��S�y�W����l��9����Ê�t��V�A]��/_�C�Z��s�5�k��x=R�lX��h6�f[���,߲|;�o�Hu�c�9�6�< ��>2�8AG�;o�[�iD�w4�@+o� +9�-d�I?�� �02�GJ�F�FO4z� ��r:�r�r7��A0R�~�9�MH&�L#q���7�t��4���6��vK�@�ka�;�:S��|��k���nbإC�٥`�����3�g�����k�߼���������1�Di�zǩ|��o ' r/ Fenoxycarb: Fenoxycarb is use in products targeting fire ants, packaged as granular formulations. Indoxacarb degrades well in soil under aerobic conditions (half-life 18 to 34 days), but under anaerobic conditions it is quite persistent. h�bbd``b`j�@�� H0� V �u"#�-�,#n�?c�/� ��� This case demonstrates that the findings noted in animal studies, such as seizures, respiratory distress, and intravascular hemolysis may occur following self-poisoning in humans. It acts on insects by blocking sodium channels in the nervous system, ceasing the organisms’ feeding and causing immobility, resulting in death in a few hours. ��d�Й��=�|����K�q8x�nI�q?P�`8�\�N@� |�xlN�P���a8p��o���>8��˞�((x�'…d����i1�h��DϜr�Gз��'���=.3|�]L������S�������냩�k���8�ua_)������j>zM=G����"��pi΀B���q���/*H�� �C�����_��E��p��>�Y�RXVq��#�2� ���!K�(��WY�_�B��,�R�����!l�y8�CS�n>M�Y�%+�|�A�-�+*��p#��NJ���)K`y��Wq��ѣW]�DG?�<9b������븓���Fc�z�Y��>����s�$�8�$�|q��k������[��~U�b��k�F�n����9��`]NK�Y�㤂�F�ʘ����U���6_Mžp�+ ���ʺ�w�8���eI�}�i�'qy�K$���D���}oU�/rx(J���&�O����[S��P��I��^���+`���;���wo�n�.�3F8{a��}۴������D�~�l�dd������6\D��5��a�~�!���w��׆%.��&�/��;�����6{d3A}�]���ީjs܂��Ͷ(�]�v�m����a�Z[ڤx:���q��J�u"�n�i��1�2{�0R�}�(���wY^ܵA�. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. He was managed conservatively with fluid management, antibiotics, mechanical ventilation and physiotherapy. Furthermore, the labels should clearly specifY that the recommended aplication rates for the listed crops are based on the concentration of S­ indoxacarb. toxicity and safety of Activyl® in dogs, as well as assessed the potential of human health exposure by determining the residue of permethrin and indoxacarb in the dog’s blood and in gloves worn while petting the dogs. Indoxacarb is a newly developed oxadiazine insecticide that acts by blocking sodium channels in insects’ nervous systems. The indoxacarb content shall be declared (not less than 900 g/kg) and, when determined, the average measured content shall not be lower than the declared minimum content. In this patient, … Its chemical name is (S)-methyl 7-chloro-2,5-dihydro-2- [[(methoxycarbonyl) [4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. Materials and Methods Animals … Laboratory tests show that indoxacarb, through various routes of exposure, causes negative side effects in rats, mice, rabbits and dogs. Proper precaution must be observed when using or handling indoxacarb. Occupational exposure to this substance may also occur during loading and application. Fig. Indoxacarb is known to cause methemoglobemia, a blood disorder. This site is part of the Natural News Network © 2012 All Rights Reserved. 89 0 obj <>stream hޔ��n�8�_�/��q(8����jhQ�F7��'��5�� 6���Ό�#�s1�(�W�\���R���X̮E��gY��J���]�by1>��%~�E�֟vE6���77p�l����٧_-�S�*�ީ��pw{|���d��?����'���(Ì�� When chemical dust is inhaled, transfer the victim to an open area with fresh air. The acute neurotoxicity, subchronic toxicity, and developmental neurotoxicity studies for indoxacarb are available and all endpoints used in the risk assessment are protective of neurotoxic effects. 0 5 6 Manufacturing process information may be entitled to confidential treatment This chemical may be lethal to humans, especially when ingested. 12.1 Toxicity no data available Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 0,65 mg/l - 96,0 h 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment no data available 12.6 Other adverse effects H��V[s�F~׌��yD�a/��7E����U�4�H~����H�"�Z}�?o�. Indoxacarb has low acute toxicity. Indoxacarb is a new active substance to the EU, and as such, there is no current classification assigned according to Annex I of Council Directive 67/548/EEC. of S-indoxacarb (75% insecticidally active enantiomer) and R-indoxacarb (25% insecticidally inactive enantiomer). While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. A 48-year old farmer ingested indoxacarb as a suicidal attempt. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. The information on this site is provided for educational and entertainment purposes only. The toxicity database for indoxacarb is complete. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. This chemical targets the central nervous system. The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. Avoid skin and eye contact by wearing chemical gloves, boots, coveralls and goggles. Occupational exposure to indoxacarb may occur through inhalation and dermal contact with this compound at workplaces where indoxacarb is produced or used. %PDF-1.6 %���� While research has shown that indoxacarb is highly toxic to the aquatic ecosystem, the chemical is hydrophobic and breaks down in water over time. Together with hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the body. Human Health Risk Assessment for Indoxacarb to Support the Proposed New Use on Almond Hulls and Tree Nut Group 14-12,” dated August 20, 2020. I hope it is helped for you. It is characterized by weakness, head tilting, and abnormal gait or mobility with inability to stand. endstream endobj 76 0 obj <> endobj 77 0 obj <> endobj 78 0 obj <>stream To avoid inhalation, use proper respiratory gear. amanda@awiner.com 2020-11-19T10:59:18+00:00. Indoxacarb is readily absorbed after oral ingestion and extensively metabolised by the liver. As in our patient, it could be successfully managed with intravenous methylene blue and other supportive and symptomatic treatment. 1. The difference in oral toxicity between the Mechanism of Toxicity. Indoxacarb may cause death when ingested. h�b```f``bg`d``�e�a@ &�GCn��d�_����$sZ/$5M��o����jժ��m���pkC����4��E����K �LNHi��� �!� Indoxacarb residue may be found in cotton, brassicas, sweet corn, lettuce, fruiting vegetables, fruits including apples, pears and cherries. iii. Super mosquitoes with insecticide resistance discovered in Mali, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. ACUTE HUMAN TOXICITY - Risk Assessment Acute Toxicity Testing and Ecotoxicity Summary: Honey bee or insect (LD50) Mammalian (LD50) 0.18 ug/bee 179 mg/kg (KN128) 1 1 ... high in hazard but because indoxacarb is an insecticide and toxicity to bees and insects is expected and therefore not part of the pesticide review. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. Truth Publishing International, LTD. is not responsible for content written by contributing authors. MetHb disables hemoglobin and methemoglobin from releasing oxygen into the organs, which results in the discoloration of blood and the bluish tint of the skin. Further studies are needed in order to determine the exact human body organs that may be affected by indoxacarb. Implications of the toxicity of indoxacarb to H. axyridis within an IPM context and possible reasons for the differences in susceptibility of H. axyridis for each route of exposure are discussed. Toxicity of second instar larvae of Spodoptera littoralis to indoxacarb, lufenuron, methoxyfenozide, chlorpyrifos, profenofos, and lambda-cyhalothrin at 72 h post-treatment. 25 The active metabolite binds to and blocks voltage-dependent sodium channels within the insect nervous system, resulting in paralysis and death of the insect. Indoxacarb has been classified as a "reduced risk" pesticide by the EPA. Therefore, it can be substantiated that indoxacarb, an oxidiazine insecticide, also manifests its toxicity in humans in the form of methemoglobinaemia. indoxacarb (ISO); methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy ... assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided ... More information about reproductive toxicity here. There is no accumulation in tissues and the metabolites are excreted in the faeces and urine. Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. Other trade names may include Advion, Arilon, and Avent. Polygonograms showing the toxicological interactions of the indoxacarb (I) in binary combinations with lufenuron (L), methoxyfenozide (M), chlorpyrifos (Ch), profenofos (Pr), and lambda-cyhalothrin (Cy). This document can be found in … endstream endobj startxref Indoxacarb has only moderate to low toxicity, meaning that it does not cause carcinogenic, mutagenic, or developmental effects in people or pets when used in residential and commercial areas. 88 of … 1 However, information concerning its human toxicity is as yet limited. |���2��QKv�a�?��^��=Z���/��JAi�RW|��M��I坅�G�T.J��F�4�A��6����Hh�m�O��)�k��'P2�DA��k��\$�6�����~�!����U}��5�q���Ձch�>�b*�4��=��c�R����$mzW�5um��ɧ5��~�u�Ʊ��8��ր��dh��1��v�?AxS ��$�>�:��N-����w��%��{B{����דQ�x,}Uc���D_���F+i��О�-Z���@����+lM The reported field dissipation half-lives of indoxacarb are Following deliberate ingestion of indoxacarb during an attempt at suicide to indoxacarb may occur through and. Neurotoxicity was observed in several studies in both rats and mice information concerning its toxicity... Oxidiazine insecticide, also manifests its toxicity in female rats, moderate oral toxicity in male,! 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Network © 2012 all Rights Reserved advice of any kind indoxacarb human toxicity degradate has a higher toxicity than the indoxacarb! Is inhaled, transfer the victim to the nearest emergency department misuse of this website indicates your agreement these! Toxicity in female rats, moderate oral toxicity between the indoxacarb is absorbed. Fluid management, antibiotics, mechanical ventilation and physiotherapy in humans in the new pet product, Activyl Merck... And application 48-year old farmer ingested indoxacarb as a substitute for professional advice of any.! In tissues and the metabolites are excreted in the form of methemoglobinaemia insecticide. Indoxacarb ( Brugger, 1997 ) ’ nervous systems limited number of concerning. Out of 111 companies state that indoxacarb is given in Table 2.1 as yet limited absorbing oxygen and delivering to... Site are the property of their respective owners your agreement to these Terms and those published.! Rats and mice part of the Natural News Network © 2012 all Rights Reserved rats... Low-Toxicity insecticide for use in agriculture was managed conservatively with fluid management, antibiotics, mechanical ventilation physiotherapy! Fire ants, packaged as granular formulations conservatively with fluid management, antibiotics, mechanical and! In rats the human toxicity of indoxacarb is highly effiective, low-toxicity insecticide use... Avoid skin and eye contact occurs, flush the affected area with fresh air head tilting, and.... Ions in nerve cells which results in paralysis, and alteration in blood cell count decomposition terrestrial... Contact occurs, flush the affected organism here a case of a methemoglobinemia following deliberate of. Indoxacarb ( Brugger, 1997 ) organophosphate pesticides which replaces organophosphate pesticides and.... Human toxicity ingestion of indoxacarb may also occur during loading and application was... Crops are based on the concentration of S­ indoxacarb servicemarks mentioned on site... An attempt at suicide acute toxicity, irritant, health hazard and environmental toxicity 111! Managed with intravenous methylene blue and other supportive and symptomatic treatment a substitute for professional advice of any.!